A.2 Loss of muscle metabolic flexibility
Metabolic flexibility is defined as the ability of the
body to respond or adapt to energy or metabolic demands
in a given situation. It has been linked to the generation
of insulin resistance, obesity and type 2 diabetes mellitus
(Goodpaster & Sparks, 2017). Mitochondrial oxidative
function and metabolic flexibility are affected during the
first weeks of rest as mitochondrial protein transcription
lessens, signalling pathways related to mitochondrial biogenesis
decrease and there is a significant fall in mitochondrial
enzyme activity. Some of these changes are already visible
48 hours after the start of inactivity. This mitochondrial
dysfunction leads to lower glucose transport by GLUT4
generating resistance to the action of insulin (Tipton, 2015),
which also later on impacts the build-up of total body fat.
me hacía una paja y me iba a dormir
y no porque me apetezca ninguna de las dos en particular, si no porque me cago en vuestra puta madre
la barba de unos días está bien pero yo digo la barbota, que yo no sé hasta qué punto la peña se la lava y enjabona a diario
que ojo, he tenido exes con barbota porque una cosa no quita la otra pero por preferir prefiero una cara limpia
